Details
Factory sells 4-(Trifluoromethoxy)benzoic acid 330-12-1 with sufficient production capacity
- Molecular Formula: C8H5F3O3
- Molecular Weight: 206.121
- Appearance/Colour: white to light yellow crystal powder
- Vapor Pressure: 0.0373mmHg at 25°C
- Melting Point: 150-154 °C(lit.)
- Refractive Index: 1.478
- Boiling Point: 230.207 °C at 760 mmHg
- PKA: 3.85±0.10(Predicted)
- Flash Point: 93.026 °C
- PSA： 46.53000
- Density: 1.448 g/cm3
- LogP: 2.28340
4-(Trifluoromethoxy)benzoic acid(Cas 330-12-1) Usage
InChI:InChI=1/C8H5F3O3/c9-8(10,11)14-6-3-1-5(2-4-6)7(12)13/h1-4H,(H,12,13)
330-12-1 Relevant articles
Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides
O'Brien, Connor J.,Nicewicz, David A.
supporting information, p. 814 - 816 (2021/03/01)
The use of carbon dioxide as a C1 chemic...
An Anionic, Chelating C(sp3)/NHC ligand from the Combination of an N-heterobicyclic Carbene and Barbituric Heterocycle
Benaissa, Idir,Gajda, Katarzyna,Vendier, Laure,Lugan, No?l,Kajetanowicz, Anna,Grela, Karol,Michelet, Véronique,César, Vincent,Bastin, Stéphanie
, p. 3223 - 3234 (2021/09/30)
The coordination chemistry of the anioni...
1,2-Dibutoxyethane-Promoted Oxidative Cleavage of Olefins into Carboxylic Acids Using O2 under Clean Conditions
Ou, Jinhua,Tan, Hong,He, Saiyu,Wang, Wei,Hu, Bonian,Yu, Gang,Liu, Kaijian
, p. 14974 - 14982 (2021/10/25)
Herein, we report the first example of a...
Radical C?H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide
Dix, Stefan,Golz, Paul,Schmid, Jonas R.,Riedel, Sebastian,Hopkinson, Matthew N.
supporting information, p. 11554 - 11558 (2021/07/09)
Trifluoromethoxylated (hetero)arenes are...
330-12-1 Process route
-
-
1736-74-9
4-trifluoromethoxybenzyl alcohol
-
-
330-12-1
4-trifluoromethoxybenzoic acid
| Conditions | Yield |
|---|---|
|
With
oxygen;
at 120 ℃;
for 9h;
Green chemistry;
|
96%
|
|
With
diethylene glycol dimethyl ether;
at 70 ℃;
for 0.583333h;
Sonication;
|
96%
|
|
4-trifluoromethoxybenzyl alcohol;
With
((CH3C6H4CH(CH3)2)RuI(C6H4NC3H2NCH3)); potassium hydroxide;
In
m-xylene;
for 16h;
Schlenk technique;
Reflux;
With
hydrogenchloride;
In
water; m-xylene;
pH=2;
Schlenk technique;
|
75%
|
|
Multi-step reaction
with
2
steps
1: chloro(η6
-p-cymene)[2-(2,6-diisopropylphenyl)-5-(1,3-diisopropyl-2,4,6-trioxohexahydropyrimidin-5-yl-κC5
)imidazo[1,5-a]pyridin-3-ylidene-κC3
]ruthenium(II); potassium hydroxide / dichloromethane; o-xylene / 150 °C / Schlenk technique
2: hydrogenchloride / water / pH 2 / Schlenk technique
With
hydrogenchloride; chloro(η6-p-cymene)[2-(2,6-diisopropylphenyl)-5-(1,3-diisopropyl-2,4,6-trioxohexahydropyrimidin-5-yl-κC5)imidazo[1,5-a]pyridin-3-ylidene-κC3]ruthenium(II); potassium hydroxide;
In
dichloromethane; o-xylene; water;
|
-
-
124-38-9,18923-20-1
carbon dioxide
-
-
407-14-7
1-bromo-4-(trifluoromethoxy)benzene
-
-
330-12-1
4-trifluoromethoxybenzoic acid
| Conditions | Yield |
|---|---|
|
1-bromo-4-(trifluoromethoxy)benzene;
With
n-butyllithium;
In
diethyl ether; hexane;
at -75 ℃;
for 0.75h;
carbon dioxide;
In
diethyl ether; hexane;
at -78 ℃;
Further stages.;
|
95%
|
|
1-bromo-4-(trifluoromethoxy)benzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
carbon dioxide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
|
69%
|
330-12-1 Upstream products
-
124-38-9
carbon dioxide
-
407-14-7
1-bromo-4-(trifluoromethoxy)benzene
-
332-25-2
4-(trifluoromethoxy)benzonitrile
-
50824-05-0
4-trifluoromethoxybenzyl bromide
330-12-1 Downstream products
-
52333-86-5
2-(4-trifluoromethoxyphenyl)oxazolo[4,5-b]pyridine
-
27914-35-8
C22 H22 F6 N2 O4
-
27914-45-0
C23 H22 F6 N2 O5
-
28510-16-9
C23 H20 F6 N2 O4
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