10-(Chloroacetyl)-10H-phenothiazine

  • CasNo:786-50-5
  • purity:99%
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1.What is the 10-(Chloroacetyl)-10H-phenothiazine ?

10-(Chloroacetyl)-10H-phenothiazine is useful in the synthesis of phenstatin analogues which exhibits anti-proliferative activity and interaction with tubulin.

10H-phenothiazine
92-84-2

10H-phenothiazine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

10-chloroacetylphenothiazine
786-50-5

10-chloroacetylphenothiazine

Conditions
Conditions Yield
In toluene; at 0 - 80 ℃; for 12h;
95%
In toluene; for 0.166667h; Microwave irradiation;
92%
In benzene; at 0 - 60 ℃;
85%
In toluene; for 5h; Reflux;
75%
In toluene; at 90 ℃; for 4h; Inert atmosphere;
71%
With triethylamine; In methanol; for 10h; Reflux;
70%
With potassium carbonate; In acetone; at 0 - 15 ℃;
56.5%
With triethylamine; In dichloromethane; Reflux;
50%
With triethylamine; In dichloromethane; for 2h; Heating;
49.5%
at 20 ℃; Cooling; Alkaline conditions;
48.1%
In benzene;
With phosphorus pentoxide; In benzene; for 3h; Heating;
In benzene; for 1h; Ambient temperature;
In toluene; Heating;
In toluene;
In benzene; Heating;
In benzene; at 0.5 ℃; for 2h;
With triethylamine; In N,N-dimethyl-formamide; at -10 - 0 ℃; for 3h;
In toluene; at 80 ℃; for 8h;
With potassium carbonate; In dichloromethane; at 20 ℃;
In benzene; at 0 ℃; Reflux;
10-chloroacetylphenothiazine
786-50-5

10-chloroacetylphenothiazine

Conditions
Conditions Yield
/BRN= 143237/ u.ClCH2COCl ;
Phenothiazin (1), Chloracetylchlorid;
Beim Erwaermen von Phenothiazin in Benzol mit Chloracetylchlorid;

2.What is the CAS number for 10-(Chloroacetyl)-10H-phenothiazine ?

The CAS number of 10-(Chloroacetyl)-10H-phenothiazine is 786-50-5.

More information of 10-(Chloroacetyl)-10H-phenothiazine 786-50-5 are:

CAS?Number

786-50-5

Density

1.383g/cm3

Boiling Point

498.6°Cat760mmHg

Flash Point

255.3°C

Vapor Pressure

4.49E-10mmHg at 25°C

Refractive Index

1.676

HS CODE

2934999090

PSA

45.61000

LogP

4.11970

3.What are another words for 10-(Chloroacetyl)-10H-phenothiazine ?

Synonyms?for?10-(Chloroacetyl)-10H-phenothiazine 786-50-5:2-chloro-1-phenothiazin-10-ylethan-1-one;N10-chloroacetyl-10H-phenothiazine;

4.What is the molecular formula of 10-(Chloroacetyl)-10H-phenothiazine?

The chemical formula of ?10-(Chloroacetyl)-10H-phenothiazine is?C14H10ClNOS which containing 14 Carbon atoms,10 Hydrogen atoms,1 Chlorine atoms,1 Nitrogen atoms,1 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of??10-(Chloroacetyl)-10H-phenothiazine?is 275.759.

5.What is 10-(Chloroacetyl)-10H-phenothiazine (786-50-5) used for?

10-(Chloroacetyl)-10H-phenothiazine is a chemical compound with the molecular formula C15H11ClNOS. It is a derivative of phenothiazine, a heterocyclic compound with a tricyclic structure consisting of two benzene rings and a thiazine ring. The chloroacetyl group is attached to the 10th position of the phenothiazine molecule, which gives it unique chemical properties and potential applications in various fields, such as pharmaceuticals and chemical research. 10-(Chloroacetyl)-10H-phenothiazine is known for its reactivity and can be used as an intermediate in the synthesis of other phenothiazine-based compounds. It is important to handle this substance with care due to its potential toxicity and reactivity.

InChI:InChI=1/C14H10ClNOS/c15-9-14(17)16-10-5-1-3-7-12(10)18-13-8-4-2-6-11(13)16/h1-8H,9H2

Relevant articles related to 10-(Chloroacetyl)-10H-phenothiazine:

Article

Source

Benzylidene thiazolidinediones: Synthesis, in vitro investigations of antiproliferative mechanisms and in vivo efficacy determination in combination with Imatinib

Joshi, Hardik,Patil, Vijay,Tilekar, Kalpana,Upadhyay, Neha,Gota, Vikram,Ramaa

supporting information, (2020/10/02)

Phenothiazines nitric oxide donor, its preparation and use

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Paragraph 0047-0050, (2018/04/20)

6.Buy 10-(Chloroacetyl)-10H-phenothiazine with the best price .

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