Details
Quality manufacturer supply 2-Chloro-3-nitropyridine 5470-18-8 in stock with high standard
- Molecular Formula: C5H3ClN2O2
- Molecular Weight: 158.544
- Appearance/Colour: yellow crystalline powder
- Melting Point: 100-103 °C(lit.)
- Refractive Index: 1.454-1.456
- Boiling Point: 260.3 °C at 760 mmHg
- PKA: -2.60±0.10(Predicted)
- Flash Point: 111.2 °C
- PSA： 58.71000
- Density: 1.489 g/cm3
- LogP: 2.16640
2-Chloro-3-nitropyridine(Cas 5470-18-8) Usage
|
Purification Methods |
It forms needles from H2O. Purify it by continuous sublimation over a period of 2 weeks at 50-60o/0.1mm [Barlin J Chem Soc 2150 1964]. The N-oxide has m 100o(from CH2Cl2/Et2O). [Taylor & Driscoll J Org Chem 25 1716 1960, Ochiai & Kaneko Chem Pharm Bull Jpn 8 28 1960, Beilstein 20/5 V 451.] |
InChI:InChI=1/C5H3ClN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
5470-18-8 Relevant articles
Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions
Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming
supporting information, p. 5565 - 5570 (2019/10/22)
A convenient and efficient method for th...
Preparation method of non-transition metal-catalyzed 2-halogenated pyridine compound
-
Paragraph 0060-0062, (2018/10/11)
The invention provides a preparation met...
Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors
Chun, Kwangwoo,Park, Ji-Seon,Lee, Han-Chang,Kim, Young-Ha,Ye, In-Hea,Kim, Kang-Jeon,Ku, Il-Whea,Noh, Min-Young,Cho, Goang-Won,Kim, Heejaung,Kim, Seung Hyun,Kim, Jeongmin
, p. 3983 - 3987 (2013/07/27)
New potent glycogen synthase kinase-3 (G...
Synthesis and photochromic properties of 2-(3-nitro-2-pyridylmethyl)benzazoles
Zakhs,Ponyaev,Subbotina,El'tsov
, p. 1076 - 1087 (2007/10/03)
2-(3-Nitro-2-pyridylmethyl)benzazoles we...
5470-18-8 Process route
-
-
59290-85-6
3-nitropyridine-2-carboxylic acid
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-
5470-18-8,34515-82-7
2-Chloro-3-nitropyridine
| Conditions | Yield |
|---|---|
|
With
tert-butylhypochlorite; sodium carbonate; sodium chloride;
In
dichloromethane;
at 25 ℃;
for 20h;
Schlenk technique;
|
58%
|
|
With
tert-butylhypochlorite; dichloromethane; oxygen; sodium hydrogencarbonate;
at 60 ℃;
for 20h;
Green chemistry;
|
47%
|
-
-
6332-56-5
2-hydroxy-3-nitropyridine
-
-
5470-18-8,34515-82-7
2-Chloro-3-nitropyridine
| Conditions | Yield |
|---|---|
|
With
phosphorus pentachloride;
|
|
|
With
phosphorus pentachloride; trichlorophosphate;
|
|
|
With
N,N-dimethyl-formamide; trichlorophosphate;
|
|
|
With
thionyl chloride;
In
N,N-dimethyl-formamide;
at 110 ℃;
for 3h;
|
5470-18-8 Upstream products
-
4214-75-9
2-amino-3-nitropyridine
-
6332-56-5
2-hydroxy-3-nitropyridine
-
2403-01-2
3-nitropyridine N-oxide
-
31594-44-2
2-ethoxy-3-nitro-pyridine
5470-18-8 Downstream products
-
26930-71-2
3-nitro-2-(piperidin-1-yl)pyridine
-
58443-06-4
2-propoxy-[3]pyridylamine
-
76893-44-2
3-nitropyridine-2-phenyl ether
-
790704-35-7
3-nitro-2-(2-nitro-phenoxy)-pyridine
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