Details
Quality products?make an important contribution to long-term revenue and profitability. Cost-effective and customizable 1H-indole-3-propylamine 6245-89-2 supplier
1.What is the 1H-indole-3-propylamine ?
-
-
5814-93-7
3-(3-indolyl)-propanamide
-
-
6245-89-2
Homotryptamine
| Conditions | Yield |
|---|---|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 24h;
Reflux;
|
100%
|
|
3-(3-indolyl)-propanamide;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
Reflux;
With
water; sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
|
94%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
|
94%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
|
92%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 3h;
Heating;
|
86%
|
|
With
lithium aluminium tetrahydride;
In
1,4-dioxane;
at 100 ℃;
|
17%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
Inert atmosphere;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 2h;
Reflux;
Inert atmosphere;
Cooling with ice;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 70 ℃;
for 3h;
Inert atmosphere;
|
2.86 g
|
-
-
830-96-6
Indole-3-propionic acid
-
-
6245-89-2
Homotryptamine
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 °C
1.2: 96 percent / NH3
(g) / tetrahydrofuran / 2.5 h / 20 °C
2.1: 86 percent / LiAlH4
/ tetrahydrofuran / 3 h / Heating
With
lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
|
|
|
Multi-step reaction
with
3
steps
1: 88 percent / HCl / 48 h / 20 °C
2: 90 percent / ammonia / methanol / 48 h / 20 °C
3: LiAlH4
/ tetrahydrofuran / 24 h / 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; ammonia;
In
tetrahydrofuran; methanol;
|
|
|
Multi-step reaction
with
4
steps
1: sulfuric acid / 20 h / Reflux
2: diisobutylaluminium hydride / toluene / -78 °C
3: hydroxylamine hydrochloride; sodium carbonate / ethanol; water
4: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol
With
sodium tetrahydroborate; nickel(II) chloride hexahydrate; sulfuric acid; hydroxylamine hydrochloride; diisobutylaluminium hydride; sodium carbonate;
In
methanol; ethanol; water; toluene;
|
|
|
Multi-step reaction
with
2
steps
1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran
2: lithium aluminium tetrahydride / tetrahydrofuran
With
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran;
|
|
|
Multi-step reaction
with
4
steps
1: boron trifluoride diethyl etherate / tetrahydrofuran / 48 h / 0 - 20 °C
2: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3: sodium azide / N,N-dimethyl-formamide / 60 °C
4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran
With
sodium azide; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
With
4-methyl-morpholine; lithium aluminium tetrahydride; ammonium chloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.75 h / 20 °C
1.2: 16 h
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / Reflux
With
lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
|
|
|
Multi-step reaction
with
2
steps
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 70 °C / Inert atmosphere
With
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran;
|
|
|
Indole-3-propionic acid;
With
ammonium hydroxide; 1,1'-carbonyldiimidazole;
Inert atmosphere;
Schlenk technique;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
Inert atmosphere;
Schlenk technique;
|
|
|
Multi-step reaction
with
5
steps
1.1: sulfuric acid / 5 h / Reflux
2.1: dmap / tetrahydrofuran / 16 h / 20 °C
3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / 20 °C
4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.2: 2 h / 0 °C / Inert atmosphere
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 - 70 °C
With
dmap; lithium aluminium tetrahydride; lithium hydroxide monohydrate; sulfuric acid; triethylamine;
In
tetrahydrofuran; water;
|
2.What is the CAS number for 1H-indole-3-propylamine ?
The CAS number of 1H-indole-3-propylamine is 6245-89-2.
More information of 1H-indole-3-propylamine 6245-89-2 are:
|
CAS?Number |
6245-89-2 |
|
Density |
1.125g/cm3 |
|
Melting Point |
64 °C |
|
Boiling Point |
353.725°C at 760 mmHg |
|
Flash Point |
194.877°C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.646 |
|
HS CODE |
2933990090 |
|
PSA |
27.82000 |
|
LogP |
3.06280 |
|
Pka |
17.29±0.30(Predicted) |
3.What are another words for 1H-indole-3-propylamine ?
Synonyms?for?1H-indole-3-propylamine 6245-89-2:Indole,3-(3-aminopropyl)- (6CI,7CI,8CI); 3-(1H-Indol-3-yl)-1-propanamine;3-(1H-Indol-3-yl)propylamine; 3-(3-Aminopropyl)indole; 3-(3-Indolyl)propylamine;3-(Indol-3-yl)propan-1-amine; 3-Indolepropylamine; 3-Indolylpropylamine;Homotryptamine; Indole-3-propanamine; g-3-Indolylpropylamine
4.What is the molecular formula of 1H-indole-3-propylamine?
The chemical formula of ?1H-indole-3-propylamine is?C11H14 N2 which containing 11 Carbon atoms,14 Hydrogen atoms and 2 Nitrogen atoms,and the molecular weight of??1H-indole-3-propylamine?is 174.246.
5.What is 1H-indole-3-propylamine (6245-89-2) used for?
1H-Indole-3-propylamine (homotryptamine) is a structural motif of interest in medicinal chemistry, particularly for its role in serotonin-related drug discovery. The study highlights a method to synthesize conformationally restricted homotryptamine derivatives via asymmetric cyclopropanation, enhancing binding potency to serotonin transporters, as demonstrated by the improved efficacy of BMS-505130 compared to flexible analogues. This approach provides a scalable and efficient route to pharmacologically relevant compounds.
InChI:InChI=1/C11H14N2/c12-7-3-4-9-8-13-11-6-2-1-5-10(9)11/h1-2,5-6,8,13H,3-4,7,12H2
Relevant articles related to 1H-indole-3-propylamine:
|
Article |
Source |
|
Synthesis of CF3-Containing Spirocyclic Indolines via a Red-Light-Mediated Trifluoromethylation/Dearomatization Cascade |
Gianetti, Thomas L.,Mei, Liangyong,Moutet, Jules,Stull, Savannah M. , p. 10640 - 10653 (2021/07/31) |
|
Hypervalent Iodine-Mediated Cyclization of Homotryptamine Derivatives |
Jiang, Xinpeng,Zhu, Weijie,Yang, Liechao,Zheng, Zicong,Yu, Chuanming supporting information, p. 2268 - 2274 (2019/04/03) |
6.Buy 1H-indole-3-propylamine with the best price .
Anhui Hefei Aiersen Chemicals Co,.Ltd is a quality supplier of 1H-indole-3-propylamine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 1H-indole-3-propylamine 6245-89-2.
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